Our Publications

A blood biomarker of the pace of aging is associated with brain structure: Replication across three cohorts
Whitman ET, Ryan CP, Abraham WC, Addae A, Corcoran DL, Elliott ML, Hogan S, Ireland D, Keenan R, Knodt AR, Melzer TR, Poulton R, Ramrakha S, Sugden K, Williams BS, Zhou J, Hariri AR, Belsky DW, Moffitt TE, Caspi A
2024. Neurobiology of Aging.
Which types of stress are associated with accelerated biological aging? Comparing perceived stress, stressful life events, childhood adversity, and posttraumatic stress disorder
Bourassa KJ, Caspi A, Brennan GM, Hall KS, Harrington HL, Houts R, Kimbrel NA, Poulton P, Ramrakha S, Taylor GA, Moffitt TE
2023. Psychosomatic Medicine.
Accelerated pace of aging in schizophrenia: Five case-control studies
Caspi A, Shireby G, Mill J, Moffitt TE, Sugden K, Hannon E
2023. Biological Psychiatry.
Cross-national and cross-generational evidence that educational attainment may slow the pace of aging in European-descent individuals
Sugden K, Moffitt TE, Arpawong TE, Belsky DW, Corcoran DL, Crimmins EM, Hannon E, Houts R, Mill JS, Poulton R, Ramrakha S, Wertz J, Williams BS, Caspi A
2023. The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences.
DunedinPACE: A DNA methylation biomarker of the Pace of Aging
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, Harrington HL, Houts R, Kothari M, Kwon D, Mill J, Schwartz J, Vokonas P, Wang C, Williams B, Moffitt TE
2022. eLife Advances.
Association of treatable health conditions during adolescence with accelerated aging at midlife
Bourassa KJ, Moffitt TE, Ambler A, Hariri AR, Harrington HL, Houts RM, Ireland D, Knodt A, Poulton R, Ramrakha S, Caspi A
2022. JAMA Pediatrics.
Life-course persistent antisocial behavior and accelerated biological aging in a longitudinal birth cohort
Langevin S, Caspi A, Barnes JC, Brennan G, Poulton R, Purdy SC, Ramrakha S, Tanksley P, Thorne PR, Wilson G, Moffitt TE
2022. International Journal of Environmental Research and Public Health.
Preparedness for healthy aging and polysubstance use in long-term cannabis users: A population-representative longitudinal study
Meier MH, Caspi A, Ambler A, Hariri AR, Harrington HL, Hogan S, Houts RM, Knodt AR, Ramrakha S, Richmond-Rakerd LS, Poulton R, Moffitt TE
2022. Lancet Healthy Longevity .
Improving risk indexes for Alzheimer's disease and related dementias for use in midlife
Reuben A, Moffitt TE, Abraham CW, Ambler A, Elliott ML, Hariri AR, Harrington HL, Hogan S, Houts RM, Ireland D, Knodt AR, Leung J, Pearson A, Poulton R, Purdy SC, Ramrakha A, Rasussen LJH, Sugden K, Thorne PR, Williams B, Wilson C, Caspi A
2022. Brain Communications.
Association of Pace of Aging measured by blood-based DNA methylation with age-related cognitive impairment and dementia.
Sugden K, Caspi A, Elliott ML, Bourassa KJ, Chamarti K, Corcoran DL, Hariri AR, Houts RM, Kothari M, Kritchevsky S, Kuchel GA, Mill JS, Williams BS, Belsky DW, Moffitt TE.
2022. Neurology.
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Elliott ML, Caspi A, Houts RM, Ambler A, Broadbent JM, Hancox RJ, Harrington HL, Hogan S, Keenan R, Knodt A, Leung JH, Melzer TR, Purdy SC, Ramrakha S, Richmond-Rakerd LS, Righarts A, Sugden K, Thomson WM, Thorne PR, Williams BS, Wilson G, Hariri AR, Poulton R, Moffitt TE
2021. Nature Aging.
Association between elevated suPAR, a new biomarker of inflammation, and accelerated aging
Rasmussen LJH, Caspi A, Ambler A, Danese A, Elliott M, Eugen-Olsen J, Hariri A, Harrington HL, Houts R, Poulton R, Ramrakha S, Sugden K, Williams BS, Moffitt TE
2021. Journal of Gerontology: Medical Sciences.
Childhood self-control forecasts the pace of midlife aging and preparedness for old age
Richmond-Rakerd LS, Caspi A, Ambler A, d'Arbeloff T, de Bruine M, Elliott M, Harrington HL, Hogan S, Houts RM, Ireland D, Keenan R, Knodt AR, Melzer TR, Park S, Poulton R, Ramrakha S, Rasmussen LJH, Sack E, Schmidt AT, Sison ML, Wertz J, Hariri AR, Moffitt TE
2021. PNAS.
Association of history of psychopathology with accelerated aging at midlife
Wertz J, Caspi A, Ambler A, Broadbent J, Hancox RJ, Harrington HL, Hogan H, Houts RM, Leung JH, Poulton R, Purdy SC, Ramrakha S, Rasmussen LJH, Richmond-Rakerd LS, Thorne PR, Wilson GA, Moffitt TE
2021. JAMA Psychiatry .
Quantification of the pace of biological aging in humans through a blood test, The DunedinPoAm DNA methylation algorithm
Belsky DW, Caspi A, Arseneault L, Corcoran DL, Hannon E, Harrington HL, Rasmussen LJH, Houts RM, Huffman K, Kraus WE, Mill J, Pieper C, Prinz J, Poulton R, Sugden K, Williams BS, Moffitt TE
2020. eLife.
Intimate partner violence and lower relationship quality are associated with faster biological aging
Bourassa KJ, Caspi A, Harrington HL, Houts RM, Poulton R, Ramrakha S, Moffitt TE
2020. Psychology and Aging.
Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth-cohort
Elliott, ML, Belsky, DW, Knodt, AR, Ireland, D, Melzer, TR, Poulton, R, Ramrakha, S, Caspi, A, Moffitt, TE, Hariri, A
2019. Molecular Psychiatry.
Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing?
Belsky DW, Moffitt TE, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A
2017. American Journal of Epidemiology.
Impact of early personal history characteristics on the pace of aging: Implications for clinical trials of therapies to slow aging and extend healthspan
Belsky DW, Caspi A, Cohen HJ, Kraus WE, Ramrakha S, Poulton R, Moffitt TE
2017. Aging Cell. (16: 644-651)
Quantification of biological aging in young adults
Belsky DW, Caspi A, Houts R, Cohen H, Corcoran DL, Danese A, Harrington HL, Israel S, Levine ME, Schaefer J, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE
2015. Proceedings of the National Academy of Sciences. (112: 4104-4110)