Meta-analysis in 2017
- Culverhouse et al., (2017). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, 00, 1–10.
Views About Gene-Environment Interaction (GxE) Research
- Duncan et al., (2014). Mind the gap: Why many geneticists and psychological scientists have discrepant views about gene-environment (GxE) research. American Psychologist, 69, 249-268.
Interesting Empirical Articles, 2015
- Rocha et al., (2015). Gene-environment interaction in youth depression: Replication of the 5-HTTLPR moderation in a diverse setting. American Journal of Psychiatry, 172, 972-985.
- Suppli et al., (2015). 5-HTTLPR and use of antidepressants after colorectal cancer, including a meta-analysis of 5-HTTLPR and depression after cancer. Translational Psychiatry, 5, e631.
Meta-analysis in 2014
- Sharpley et al. (2014) An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings. Behavioural Brain Research, 273, 89-105.
- James Tabery, a philosopher and historian of science, has written a fascinating book about the struggle to understand the interaction of nature and nurture.
Meta-analysis in 2013
- Culverhouse et al. (2013) Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression. BMC Psychiatry, 13, 304.
- Letter to Culverhouse, from Terrie Moffitt, June 21, 2012
- Response to Culverhouse et al., (2014) Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression BMC Psychiatry, 14, 179.
Media Coverage in 2012
- Can Genes Send You High or Low? The Orchid Hypothesis A-Bloom by David Dobbs Wired Science, March 20, 2012
Meta-analysis in 2011
- Karg et al. (2011) The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited. Archives of General Psychiatry, 68, 444-454.
- Hardy et al. (2011) Genes and Environment in Psychiatry:Winner's Curse or Cure? Archives of General Psychiatry, 68, 455-456.
- Blakely et al. (2011) Genetic Indeterminism, the 5-HTTLPR, and the Paths Forward in Neuropsychiatric Genetics. Archives of General Psychiatry, 68, 457-458.
Media Coverage of Karg et al.
- Resurrecting the so-called 'depression gene': new evidence that our genes play a role in our response to adversity (Science Daily, Jan. 4, 2011)
- Depression gene: its rise, its fall, its rise? (Los Angeles Times, Jan. 3, 2011)
- A Gene to Explain Depression (Time, Jan. 3, 2011)
- "Depressions Gene" Linked to Response to Stress (WebMD, Jan. 4, 2011)
- Controversial Gene-Depression Link Confirmed in New Study (Fox News, Jan. 4, 2011)
- Why Advocacy Must Be Routine Part of Our Work (Psychiatric News, Jan. 21, 2011)
Review of Research about GxE in 2010
- Caspi et al. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene (5-HTT) and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509-527.
Meta-analysis in 2009
- Risch et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. JAMA, 301, 2462-2471.
Responses to Risch et al.
- Drs. Moffitt and Caspi's Response letter for the Press
- Letters to JAMA in response to Risch et al. and Risch's reply to letters
- Rutter et al. Gene-Environment Interactions: Biologically valid of artifact? (JAMA, Dec 2009)
- Uher & McGuffin The moderation by the seratonin transporter gene of environmental adversity in the etiology of depression: 2009 update (Molecular Psychiatry, 2010)
- Kramer reply in AACAP News: GxE Depression Hypothesis Challenged: Researchers Reply (Nov/Dec 2009)
- Rutter editorial in Depression and Anxiety: Gene-Environment Interplay (2010)
- Palla et al. Challenges in the Use of Literature-based Meta-Analysis to Examine Gene-Environment Interactions (American Journal of Epidemiology Advance Access, April 20, 2010)
Media Coverage of Risch et al.
- Hunt For Depression Genes Goes Into Reverse (Forbes, June 16, 2009)
- Report on Gene for Depression Is Now Faulted (The New York Times, June 16, 2009)
- Gene plus stress equals depression debate (Science News, June 16, 2009)
- Science Now
- Study: 'Depression Gene' Doesn't Predict the Blues (Time, June 17, 2009)
- Serotonin Gene’s Link With Depression Not Valid, Says Study (The Wall Street Journal, June 16, 2009)
- The (Illusory) Rise and Fall of the "Depression Gene" (Science Blogs, June 17, 2009)
- Serotonin Gene, Even When Combined With Life Events, Has No Effect on Depression (Medscape Medical News, June 17, 2009)
- The Genetics of Complex Behaviors: It Really Isn't That Simple (Patent Docs, June 22, 2009)
- The Secrets of Serotonin (Slate, Sept. 28, 2009)
Especially Interesting Media Coverage of Original Caspi et al. Report
- A Question of Resilience by Emily Bazelon (The New York Times, April 30, 2006)
- The Long and Short of It (The Economist, July 19, 2003)