Aging: Empirical Articles

  • Association between elevated suPAR, a new biomarker of inflammation, and accelerated aging

    Rasmussen LJH, Caspi A, Ambler A, Danese A, Elliott M, Eugen-Olsen J, Hariri A, Harrington HL, Houts R, Poulton R, Ramrakha S, Sugden K, Williams BS, Moffitt TE
    2021 Journal of Gerontology: Medical Sciences

  • Childhood self-control forecasts the pace of midlife aging and preparedness for old age

    Richmond-Rakerd LS, Caspi A, Ambler A, d'Arbeloff T, de Bruine M, Elliott M, Harrington HL, Hogan S, Houts RM, Ireland D, Keenan R, Knodt AR, Melzer TR, Park S, Poulton R, Ramrakha S, Rasmussen LJH, Sack E, Schmidt AT, Sison ML, Wertz J, Hariri AR, Moffitt TE
    2021 PNAS

  • Longitudinal associations of mental disorders with physical diseases and mortality among 2.3 million New Zealanders

    Richmond-Rakerd LS, D'Souza S, Milne BJ, Caspi A, Moffitt TE
    2021 JAMA Network Open

  • Association of history of psychopathology with accelerated aging at midlife

    Wertz J, Caspi A, Ambler A, Broadbent J, Hancox RJ, Harrington HL, Hogan H, Houts RM, Leung JH, Poulton R, Purdy SC, Ramrakha S, Rasmussen LJH, Richmond-Rakerd LS, Thorne PR, Wilson GA, Moffitt TE
    2021 JAMA Psychiatry

  • Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy

    Elliott ML, Caspi A, Houts RM, Ambler A, Broadbent JM, Hancox RJ, Harrington HL, Hogan S, Keenan R, Knodt A, Leung JH, Melzer TR, Purdy SC, Ramrakha S, Richmond-Rakerd LS, Righarts A, Sugden K, Thomson WM, Thorne PR, Williams BS, Wilson G, Hariri AR, Poulton R, Moffitt TE
    2021 Nature Aging

  • White matter hyperintensities are common in midlife and already associated with cognitive decline

    d'Arbeloff, T, Elliott, ML, Knodt, AR, Melzer, TR, Keenan, R, Ireland, D, Ramrakha, S, Poulton, R, Anderson, T, Caspi, A, Moffitt, TE, Hariri, AR
    2020 Brain Communications

  • Quantification of the pace of biological aging in humans through a blood test, The DunedinPoAm DNA methylation algorithm

    Belsky DW, Caspi A, Arseneault L, Corcoran DL, Hannon E, Harrington HL, Rasmussen LJH, Houts RM, Huffman K, Kraus WE, Mill J, Pieper C, Prinz J, Poulton R, Sugden K, Williams BS, Moffitt TE
    2020 eLife

  • Intimate partner violence and lower relationship quality are associated with faster biological aging

    Bourassa KJ, Caspi A, Harrington HL, Houts RM, Poulton R, Ramrakha S, Moffitt TE
    2020 Psychology and Aging

  • Association of childhood lead exposure with MRI measurements of structural brain integrity in midlife

    Reuben A, Elliott ML, Abraham C, Broadbent J, Houts RM, Ireland D, Knodt AR, Poulton R, Ramrakha S, Hariri AR, Caspi A, Moffitt TE
    2020 JAMA

  • Psychiatry's opportunity to prevent the rising burden of age-related disease

    Moffitt TE, Caspi A
    2019 JAMA Psychiatry

  • Association of neurocognitive and physical function with gait speed in midlife

    Rasmussen, LJH, Caspi, A, Ambler, A, Broadbent, JM, Cohen, HJ, d'Arbeloff, T, Elliott, M, Hancox, RJ, Harrington, HL, Hogan, S, Houts, R, Ireland, D, Knodt, A, Meredith-Jones, M, Morey, MC, Morrison, L, Poulton, R, Ramrakha, S, Richmond-Rakerd, L, Sison, ML, Sneddon, K, Thomson, WM, Hariri, AR, Moffitt, TE
    2019 JAMA Network Open

  • Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth-cohort

    Elliott, ML, Belsky, DW, Knodt, AR, Ireland, D, Melzer, TR, Poulton, R, Ramrakha, S, Caspi, A, Moffitt, TE, Hariri, A
    2019 Molecular Psychiatry

  • Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing?

    Belsky DW, Moffitt TE, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A
    2017 American Journal of Epidemiology

  • Impact of early personal history characteristics on the pace of aging: Implications for clinical trials of therapies to slow aging and extend healthspan

    Belsky DW, Caspi A, Cohen HJ, Kraus WE, Ramrakha S, Poulton R, Moffitt TE
    2017 Aging Cell 16: 644-651

  • Lest we forget: Comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health

    Reuben A, Moffitt TE, Caspi A, Belsky DW, Harrington HL, Schroeder F, Hogan S, Ramrakha S, Poulton R, Danese A
    2016 Journal of Child Psychology and Psychiatry 57: 1103-1112

  • Quantification of biological aging in young adults

    Belsky DW, Caspi A, Houts R, Cohen H, Corcoran DL, Danese A, Harrington HL, Israel S, Levine ME, Schaefer J, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE
    2015 Proceedings of the National Academy of Sciences 112: 4104-4110

  • Early-life intelligence predicts midlife biological age

    Schaefer J, Caspi A, Belsky DW, Harrington HL, Houts R, Israel S, Levine M, Sugden K, Williams B, Poulton R, Moffitt TE
    2015 Journal of Gerontology: Psychological Sciences 71:968-977

  • Cardiorespiratory fitness and cognitive function in midlife: Neuroprotection or neuroselection?

    Belsky DW, Caspi A, Israel S, Blumenthal JA, Poulton R, Moffitt TE
    2015 Annals of Neurology 77: 607-617

  • Internalizing disorders and leukocyte telomere erosion: A prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder

    Shalev I, Moffitt TE, Braithwaite AW, Danese A, Fleming NI, Goldman-Mellor S, Harrington HL, Houts R, Israel S, Poulton R, Robertson SP, Sugden K, Williams B, Caspi A
    2014 Molecular Psychiatry 1-8

  • Perinatal complications and aging indicators by midlife

    Shalev I, Caspi A, Ambler A, Belsky DW, Chapple S, Cohen H, Salomon I, Poulton R, Ramrakha S, Rivera C, Sugden K, Williams B, Wolke D, Moffitt TE
    2014 Pediatrics 134:1315-1323

  • Is chronic asthma associated with shorter leukocyte telomere length at midlife?

    Belsky DW, Shalev I, Sears MR, Hancox RJ, Harrington HL, Houts R, Moffitt TE, Sugden K, Williams B, Poulton R, Caspi A
    2014 American Journal of Respiratory and Critical Care Medicine 190:384-391

  • Retinal vessel caliber and neuropsychological functioning: An investigative tool for cognitive epidemiology

    Shalev I, Moffitt TE, Wong TY, Meier MH, Ding J, Cheung CY, Ikram KM, Caspi A, Poulton R
    2013 Psychological Science 24:1198-1207