Aging: Empirical Articles

Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Elliott ML, Caspi A, Houts RM, Ambler A, Broadbent JM, Hancox RJ, Harrington HL, Hogan S, Keenan R, Knodt A, Leung JH, Melzer TR, Purdy SC, Ramrakha S, Richmond-Rakerd LS, Righarts A, Sugden K, Thomson WM, Thorne PR, Williams BS, Wilson G, Hariri AR, Poulton R, Moffitt TE
2021. Nature Aging.
Association between elevated suPAR, a new biomarker of inflammation, and accelerated aging
Rasmussen LJH, Caspi A, Ambler A, Danese A, Elliott M, Eugen-Olsen J, Hariri A, Harrington HL, Houts R, Poulton R, Ramrakha S, Sugden K, Williams BS, Moffitt TE
2021. Journal of Gerontology: Medical Sciences.
Childhood self-control forecasts the pace of midlife aging and preparedness for old age
Richmond-Rakerd LS, Caspi A, Ambler A, d'Arbeloff T, de Bruine M, Elliott M, Harrington HL, Hogan S, Houts RM, Ireland D, Keenan R, Knodt AR, Melzer TR, Park S, Poulton R, Ramrakha S, Rasmussen LJH, Sack E, Schmidt AT, Sison ML, Wertz J, Hariri AR, Moffitt TE
2021. PNAS.
Longitudinal associations of mental disorders with physical diseases and mortality among 2.3 million New Zealanders
Richmond-Rakerd LS, D'Souza S, Milne BJ, Caspi A, Moffitt TE
2021. JAMA Network Open.
Association of history of psychopathology with accelerated aging at midlife
Wertz J, Caspi A, Ambler A, Broadbent J, Hancox RJ, Harrington HL, Hogan H, Houts RM, Leung JH, Poulton R, Purdy SC, Ramrakha S, Rasmussen LJH, Richmond-Rakerd LS, Thorne PR, Wilson GA, Moffitt TE
2021. JAMA Psychiatry .
Quantification of the pace of biological aging in humans through a blood test, The DunedinPoAm DNA methylation algorithm
Belsky DW, Caspi A, Arseneault L, Corcoran DL, Hannon E, Harrington HL, Rasmussen LJH, Houts RM, Huffman K, Kraus WE, Mill J, Pieper C, Prinz J, Poulton R, Sugden K, Williams BS, Moffitt TE
2020. eLife.
Intimate partner violence and lower relationship quality are associated with faster biological aging
Bourassa KJ, Caspi A, Harrington HL, Houts RM, Poulton R, Ramrakha S, Moffitt TE
2020. Psychology and Aging.
White matter hyperintensities are common in midlife and already associated with cognitive decline
d'Arbeloff, T, Elliott, ML, Knodt, AR, Melzer, TR, Keenan, R, Ireland, D, Ramrakha, S, Poulton, R, Anderson, T, Caspi, A, Moffitt, TE, Hariri, AR
2020. Brain Communications.
Association of childhood lead exposure with MRI measurements of structural brain integrity in midlife
Reuben A, Elliott ML, Abraham C, Broadbent J, Houts RM, Ireland D, Knodt AR, Poulton R, Ramrakha S, Hariri AR, Caspi A, Moffitt TE
2020. JAMA.
Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth-cohort
Elliott, ML, Belsky, DW, Knodt, AR, Ireland, D, Melzer, TR, Poulton, R, Ramrakha, S, Caspi, A, Moffitt, TE, Hariri, A
2019. Molecular Psychiatry.
Psychiatry's opportunity to prevent the rising burden of age-related disease
Moffitt TE, Caspi A
2019. JAMA Psychiatry .
Association of neurocognitive and physical function with gait speed in midlife
Rasmussen, LJH, Caspi, A, Ambler, A, Broadbent, JM, Cohen, HJ, d'Arbeloff, T, Elliott, M, Hancox, RJ, Harrington, HL, Hogan, S, Houts, R, Ireland, D, Knodt, A, Meredith-Jones, M, Morey, MC, Morrison, L, Poulton, R, Ramrakha, S, Richmond-Rakerd, L, Sison, ML, Sneddon, K, Thomson, WM, Hariri, AR, Moffitt, TE
2019. JAMA Network Open.
Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing?
Belsky DW, Moffitt TE, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A
2017. American Journal of Epidemiology.
Impact of early personal history characteristics on the pace of aging: Implications for clinical trials of therapies to slow aging and extend healthspan
Belsky DW, Caspi A, Cohen HJ, Kraus WE, Ramrakha S, Poulton R, Moffitt TE
2017. Aging Cell. (16: 644-651)
Lest we forget: Comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health
Reuben A, Moffitt TE, Caspi A, Belsky DW, Harrington HL, Schroeder F, Hogan S, Ramrakha S, Poulton R, Danese A
2016. Journal of Child Psychology and Psychiatry. (57: 1103-1112)
Quantification of biological aging in young adults
Belsky DW, Caspi A, Houts R, Cohen H, Corcoran DL, Danese A, Harrington HL, Israel S, Levine ME, Schaefer J, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE
2015. Proceedings of the National Academy of Sciences. (112: 4104-4110)
Cardiorespiratory fitness and cognitive function in midlife: Neuroprotection or neuroselection?
Belsky DW, Caspi A, Israel S, Blumenthal JA, Poulton R, Moffitt TE
2015. Annals of Neurology. (77: 607-617)
Early-life intelligence predicts midlife biological age
Schaefer J, Caspi A, Belsky DW, Harrington HL, Houts R, Israel S, Levine M, Sugden K, Williams B, Poulton R, Moffitt TE
2015. Journal of Gerontology: Psychological Sciences. (71:968-977)
Is chronic asthma associated with shorter leukocyte telomere length at midlife?
Belsky DW, Shalev I, Sears MR, Hancox RJ, Harrington HL, Houts R, Moffitt TE, Sugden K, Williams B, Poulton R, Caspi A
2014. American Journal of Respiratory and Critical Care Medicine. (190:384-391)
Perinatal complications and aging indicators by midlife
Shalev I, Caspi A, Ambler A, Belsky DW, Chapple S, Cohen H, Salomon I, Poulton R, Ramrakha S, Rivera C, Sugden K, Williams B, Wolke D, Moffitt TE
2014. Pediatrics. (134:1315-1323)
Internalizing disorders and leukocyte telomere erosion: A prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder
Shalev I, Moffitt TE, Braithwaite AW, Danese A, Fleming NI, Goldman-Mellor S, Harrington HL, Houts R, Israel S, Poulton R, Robertson SP, Sugden K, Williams B, Caspi A
2014. Molecular Psychiatry. (1-8)
Retinal vessel caliber and neuropsychological functioning: An investigative tool for cognitive epidemiology
Shalev I, Moffitt TE, Wong TY, Meier MH, Ding J, Cheung CY, Ikram KM, Caspi A, Poulton R
2013. Psychological Science. (24:1198-1207)