Which types of stress are associated with accelerated biological aging? Comparing perceived stress, stressful life events, childhood adversity, and posttraumatic stress disorder
Bourassa KJ, Caspi A, Brennan GM, Hall KS, Harrington HL, Houts R, Kimbrel NA, Poulton P, Ramrakha S, Taylor GA, Moffitt TE2023. Psychosomatic Medicine.
Cross-national and cross-generational evidence that educational attainment may slow the pace of aging in European-descent individuals
Sugden K, Moffitt TE, Arpawong TE, Belsky DW, Corcoran DL, Crimmins EM, Hannon E, Houts R, Mill JS, Poulton R, Ramrakha S, Wertz J, Williams BS, Caspi A2023. The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences.
DunedinPACE: A DNA methylation biomarker of the Pace of Aging
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, Harrington HL, Houts R, Kothari M, Kwon D, Mill J, Schwartz J, Vokonas P, Wang C, Williams B, Moffitt TE2022. eLife Advances.
Association of treatable health conditions during adolescence with accelerated aging at midlife
Bourassa KJ, Moffitt TE, Ambler A, Hariri AR, Harrington HL, Houts RM, Ireland D, Knodt A, Poulton R, Ramrakha S, Caspi A2022. JAMA Pediatrics.
Long-term cannabis use and cognitive reserves and hippocampal volume in midlife
Meier MH, Caspi A, Knodt AR, Hall W, Ambler A, Harrington HL, Hogan S, Houts RM, Poulton R, Ramrakha S, Hariri AR, Moffitt TE2022. American Journal of Psychiatry.
Improving risk indexes for Alzheimer's disease and related dementias for use in midlife
Reuben A, Moffitt TE, Abraham CW, Ambler A, Elliott ML, Hariri AR, Harrington HL, Hogan S, Houts RM, Ireland D, Knodt AR, Leung J, Pearson A, Poulton R, Purdy SC, Ramrakha A, Rasussen LJH, Sugden K, Thorne PR, Williams B, Wilson C, Caspi A2022. Brain Communications.
Longitudinal associations of mental disorders with dementia: 30-year analysis of 1.7 million citizens
Richmond-Rakerd LS, D'Souza S, Milne BJ, Caspi A, Moffitt TE2022. JAMA Psychiatry.
Association of Pace of Aging measured by blood-based DNA methylation with age-related cognitive impairment and dementia.
Sugden K, Caspi A, Elliott ML, Bourassa KJ, Chamarti K, Corcoran DL, Hariri AR, Houts RM, Kothari M, Kritchevsky S, Kuchel GA, Mill JS, Williams BS, Belsky DW, Moffitt TE.2022. Neurology.
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Elliott ML, Caspi A, Houts RM, Ambler A, Broadbent JM, Hancox RJ, Harrington HL, Hogan S, Keenan R, Knodt A, Leung JH, Melzer TR, Purdy SC, Ramrakha S, Richmond-Rakerd LS, Righarts A, Sugden K, Thomson WM, Thorne PR, Williams BS, Wilson G, Hariri AR, Poulton R, Moffitt TE2021. Nature Aging.
Association between elevated suPAR, a new biomarker of inflammation, and accelerated aging
Rasmussen LJH, Caspi A, Ambler A, Danese A, Elliott M, Eugen-Olsen J, Hariri A, Harrington HL, Houts R, Poulton R, Ramrakha S, Sugden K, Williams BS, Moffitt TE2021. Journal of Gerontology: Medical Sciences.
Longitudinal associations of mental disorders with physical diseases and mortality among 2.3 million New Zealanders
Richmond-Rakerd LS, D'Souza S, Milne BJ, Caspi A, Moffitt TE2021. JAMA Network Open.
Childhood self-control forecasts the pace of midlife aging and preparedness for old age
Richmond-Rakerd LS, Caspi A, Ambler A, d'Arbeloff T, de Bruine M, Elliott M, Harrington HL, Hogan S, Houts RM, Ireland D, Keenan R, Knodt AR, Melzer TR, Park S, Poulton R, Ramrakha S, Rasmussen LJH, Sack E, Schmidt AT, Sison ML, Wertz J, Hariri AR, Moffitt TE2021. PNAS.
Association of history of psychopathology with accelerated aging at midlife
Wertz J, Caspi A, Ambler A, Broadbent J, Hancox RJ, Harrington HL, Hogan H, Houts RM, Leung JH, Poulton R, Purdy SC, Ramrakha S, Rasmussen LJH, Richmond-Rakerd LS, Thorne PR, Wilson GA, Moffitt TE2021. JAMA Psychiatry .
Quantification of the pace of biological aging in humans through a blood test, The DunedinPoAm DNA methylation algorithm
Belsky DW, Caspi A, Arseneault L, Corcoran DL, Hannon E, Harrington HL, Rasmussen LJH, Houts RM, Huffman K, Kraus WE, Mill J, Pieper C, Prinz J, Poulton R, Sugden K, Williams BS, Moffitt TE2020. eLife.
Intimate partner violence and lower relationship quality are associated with faster biological aging
Bourassa KJ, Caspi A, Harrington HL, Houts RM, Poulton R, Ramrakha S, Moffitt TE2020. Psychology and Aging.
White matter hyperintensities are common in midlife and already associated with cognitive decline
d'Arbeloff, T, Elliott, ML, Knodt, AR, Melzer, TR, Keenan, R, Ireland, D, Ramrakha, S, Poulton, R, Anderson, T, Caspi, A, Moffitt, TE, Hariri, AR2020. Brain Communications.
Association of childhood lead exposure with MRI measurements of structural brain integrity in midlife
Reuben A, Elliott ML, Abraham C, Broadbent J, Houts RM, Ireland D, Knodt AR, Poulton R, Ramrakha S, Hariri AR, Caspi A, Moffitt TE2020. JAMA.
Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth-cohort
Elliott, ML, Belsky, DW, Knodt, AR, Ireland, D, Melzer, TR, Poulton, R, Ramrakha, S, Caspi, A, Moffitt, TE, Hariri, A2019. Molecular Psychiatry.
Psychiatry's opportunity to prevent the rising burden of age-related disease
Moffitt TE, Caspi A2019. JAMA Psychiatry .
Association of neurocognitive and physical function with gait speed in midlife
Rasmussen, LJH, Caspi, A, Ambler, A, Broadbent, JM, Cohen, HJ, d'Arbeloff, T, Elliott, M, Hancox, RJ, Harrington, HL, Hogan, S, Houts, R, Ireland, D, Knodt, A, Meredith-Jones, M, Morey, MC, Morrison, L, Poulton, R, Ramrakha, S, Richmond-Rakerd, L, Sison, ML, Sneddon, K, Thomson, WM, Hariri, AR, Moffitt, TE2019. JAMA Network Open.
Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing?
Belsky DW, Moffitt TE, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A2017. American Journal of Epidemiology.
Impact of early personal history characteristics on the pace of aging: Implications for clinical trials of therapies to slow aging and extend healthspan
Belsky DW, Caspi A, Cohen HJ, Kraus WE, Ramrakha S, Poulton R, Moffitt TE2017. Aging Cell. (16: 644-651)
Lest we forget: Comparing retrospective and prospective assessments of adverse childhood experiences in the prediction of adult health
Reuben A, Moffitt TE, Caspi A, Belsky DW, Harrington HL, Schroeder F, Hogan S, Ramrakha S, Poulton R, Danese A2016. Journal of Child Psychology and Psychiatry. (57: 1103-1112)
Quantification of biological aging in young adults
Belsky DW, Caspi A, Houts R, Cohen H, Corcoran DL, Danese A, Harrington HL, Israel S, Levine ME, Schaefer J, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE2015. Proceedings of the National Academy of Sciences. (112: 4104-4110)
Cardiorespiratory fitness and cognitive function in midlife: Neuroprotection or neuroselection?
Belsky DW, Caspi A, Israel S, Blumenthal JA, Poulton R, Moffitt TE2015. Annals of Neurology. (77: 607-617)