Karen Sugden, Ph.D.
Research Project Mgr, University
Karen graduated from the University of Liverpool with a B.Sc in genetics and received a Ph.D. from the Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, focusing on the study of genetic and genomic influences on behavior and mental health. Her current appointment is with Duke University’s Department of Psychology and Neuroscience and Center for Genomic and Computational Biology.
Her current research focus is on the collection and analysis of biological information in large longitudinal cohorts. In particular, she is interested in applying cutting-edge molecular approaches to understand the biological mechanisms influencing normal and abnormal behavior. To this end, Karen is responsible for the curation and analysis of genetic, epigenetic and transcriptomic data in the Dunedin Longitudinal Study and the E-Risk Study. Karen also teaches and advises on methodological issues related to biomarker collection and analysis in population-based cohorts.
Away from the laboratory, Karen enjoys spending time in nature walking and bird-watching, as well as gardening, upholstery and trying to accumulate as many animals as is possible.
Belsky, Daniel W., et al. “Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.” Jama Psychiatry, vol. 70, no. 5, May 2013, pp. 534–42. Epmc, doi:10.1001/jamapsychiatry.2013.736. Full Text
Belsky, Daniel W., et al. “Development and evaluation of a genetic risk score for obesity.” Biodemography and Social Biology, vol. 59, no. 1, Jan. 2013, pp. 85–100. Epmc, doi:10.1080/19485565.2013.774628. Full Text
Belsky, Daniel W., et al. “Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study.” Arch Pediatr Adolesc Med, vol. 166, no. 6, June 2012, pp. 515–21. Pubmed, doi:10.1001/archpediatrics.2012.131. Full Text
Uher, Rudolf, et al. “Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results.” Journal of Affective Disorders, vol. 135, no. 1–3, Dec. 2011, pp. 56–65. Epmc, doi:10.1016/j.jad.2011.03.010. Full Text
Danese, A., et al. “Biological embedding of stress through inflammation processes in childhood.” Molecular Psychiatry, vol. 16, no. 3, Mar. 2011, pp. 244–46. Epmc, doi:10.1038/mp.2010.5. Full Text
Sugden, Karen, et al. “Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization.” Journal of the American Academy of Child and Adolescent Psychiatry, vol. 49, no. 8, Aug. 2010, pp. 830–40. Epmc, doi:10.1016/j.jaac.2010.01.024. Full Text
Polanczyk, Guilherme, et al. “Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.” Archives of General Psychiatry, vol. 66, no. 9, Sept. 2009, pp. 978–85. Epmc, doi:10.1001/archgenpsychiatry.2009.114. Full Text
Caspi, Avshalom, et al. “Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.” Science (New York, N.Y.), vol. 301, no. 5631, July 2003, pp. 386–89. Epmc, doi:10.1126/science.1083968. Full Text
Mill, J. S., et al. “The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study.” Molecular Psychiatry, vol. 7, no. 4, Jan. 2002, pp. 383–91. Epmc, doi:10.1038/sj.mp.4000984. Full Text