Research Project Mgr, University
Karen graduated from the University of Liverpool with a B.Sc in genetics and received a Ph.D. from the Social, Genetic and Developmental Psychiatry (SGDP) Centre, King’s College London, focusing on the study of genetic and genomic influences on behavior and mental health. Her current appointment is with Duke University’s Department of Psychology and Neuroscience and Center for Genomic and Computational Biology.
Her current research focus is on the collection and analysis of biological information in large longitudinal cohorts. In particular, she is interested in applying cutting-edge molecular approaches to understand the biological mechanisms influencing normal and abnormal behavior. To this end, Karen is responsible for the curation and analysis of genetic, epigenetic and transcriptomic data in the Dunedin Longitudinal Study and the E-Risk Study. Karen also teaches and advises on methodological issues related to biomarker collection and analysis in population-based cohorts.
Away from the laboratory, Karen enjoys spending time in nature walking and bird-watching, as well as gardening, upholstery and trying to accumulate as many animals as is possible.
Social Relationship Qualities as Predictors of Health & Aging from Adolescence thru Midlife awarded by University of Virginia - Charlottesville (Principal Investigator). 2018 to 2023
Midlife Pace of Aging in the Dunedin Study awarded by King's College London (Research Professional). 2017 to 2021
Aging in 1000 healthy young adults: the Dunedin Study awarded by National Institutes of Health (Laboratory Technician). 2009 to 2020
Rasmussen, LJH, Moffitt, TE, Eugen-Olsen, J, Belsky, DW, Danese, A, Harrington, H, Houts, RM, Poulton, R, Sugden, K, Williams, B, and Caspi, A. "Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood." Journal of Child Psychology and Psychiatry, and Allied Disciplines 60.2 (February 2019): 199-208. Full Text
Hannon, E, Knox, O, Sugden, K, Burrage, J, Wong, CCY, Belsky, DW, Corcoran, DL, Arseneault, L, Moffitt, TE, Caspi, A, and Mill, J. "Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins." Plos Genetics 14.8 (August 9, 2018): e1007544-null. Full Text
Marzi, SJ, Sugden, K, Arseneault, L, Belsky, DW, Burrage, J, Corcoran, DL, Danese, A, Fisher, HL, Hannon, E, Moffitt, TE, Odgers, CL, Pariante, C, Poulton, R, Williams, BS, Wong, CCY, Mill, J, and Caspi, A. "Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood." The American Journal of Psychiatry 175.6 (June 2018): 517-529. Full Text
Belsky, DW, Moffitt, TE, Cohen, AA, Corcoran, DL, Levine, ME, Prinz, JA, Schaefer, J, Sugden, K, Williams, B, Poulton, R, and Caspi, A. "Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?." American Journal of Epidemiology 187.6 (June 2018): 1220-1230. Full Text
Wertz, J, Caspi, A, Belsky, DW, Beckley, AL, Arseneault, L, Barnes, JC, Corcoran, DL, Hogan, S, Houts, RM, Morgan, N, Odgers, CL, Prinz, JA, Sugden, K, Williams, BS, Poulton, R, and Moffitt, TE. "Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior." Psychological Science 29.5 (May 2018): 791-803. Full Text
Baldwin, JR, Arseneault, L, Caspi, A, Fisher, HL, Moffitt, TE, Odgers, CL, Pariante, C, Ambler, A, Dove, R, Kepa, A, Matthews, T, Menard, A, Sugden, K, Williams, B, and Danese, A. "Childhood victimization and inflammation in young adulthood: A genetically sensitive cohort study." Brain, behavior, and immunity 67 (January 2018): 211-217. Full Text
Reuben, A, Caspi, A, Belsky, DW, Broadbent, J, Harrington, H, Sugden, K, Houts, RM, Ramrakha, S, Poulton, R, and Moffitt, TE. "Association of Childhood Blood Lead Levels With Cognitive Function and Socioeconomic Status at Age 38 Years and With IQ Change and Socioeconomic Mobility Between Childhood and Adulthood." Jama 317.12 (March 2017): 1244-1251. Full Text
Schaefer, JD, Caspi, A, Belsky, DW, Harrington, H, Houts, R, Israel, S, Levine, ME, Sugden, K, Williams, B, Poulton, R, and Moffitt, TE. "Early-Life Intelligence Predicts Midlife Biological Age." The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences 71.6 (November 2016): 968-977. Full Text
Belsky, DW, Moffitt, TE, Corcoran, DL, Domingue, B, Harrington, H, Hogan, S, Houts, R, Ramrakha, S, Sugden, K, Williams, BS, Poulton, R, and Caspi, A. "The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development." Psychological Science 27.7 (July 2016): 957-972. Full Text Open Access Copy
Sugden, K, Moffitt, TE, Pinto, L, Poulton, R, Williams, BS, and Caspi, A. "Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort." PLOS ONE 11.2 (February 17, 2016). Full Text